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Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells
Published on: October 11, 2012
Signaling unmasked: Autophagy and catalase promote programmed cell death
Morten Petersen1, Daniel Hofius2, Stig Uggerhøj Andersen3
1Department of Biology; University of Copenhagen; Copenhagen, Denmark.
Abstract:
Autophagy contributes to the removal of harmful cellular refuse, whereas catalase plays an important protective role by detoxifying reactive oxygen species. We recently found that autophagy and catalase are also required for promoting programmed cell death induced during plant immune responses. Here we discuss the difficulties in identifying cell death effectors, which are also required to maintain cellular homeostasis, and how their prodeath roles were unmasked using an unbiased forward genetics approach.
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