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Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals
Published on: January 5, 2016
Systemic cytokine levels show limited correlation with risk of HIV-1 acquisition
Dara A Lehman1, Keshet Ronen, Catherine A Blish
1*Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA; †Department of Global Health, University of Washington, Seattle, WA; ‡Department of Medicine, Stanford Immunology, Stanford University School of Medicine, Stanford, CA; Departments of §Medicine; ‖Epidemiology, University of Washington, Seattle, WA; ¶Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya; #Coast Provincial General Hospital, Women's Health Project, Mombasa, Kenya; **Department of Biostatistics, University of Washington, Seattle, WA; ††Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA; and ‡‡Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
Abstract:
It has been hypothesized that immune activation and inflammation may increase HIV-1 susceptibility, and that cytokines may be useful biomarkers for risk. Within a prospective cohort, we conducted a nested case-control analysis of plasma cytokine levels among women who acquired HIV-1 <3 months after sampling, compared with 3 different control groups. We observed associations between lower interleukin (IL)-6 and IL-10 and higher IL-7 levels with HIV-1 acquisition, however, these associations were inconsistent when comparing with different control groups. Inconsistent results within our study and among previous studies suggest that reproducible findings are needed before cytokines are useful biomarkers for HIV-1 susceptibility.
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