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Updated: May 4, 2026

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis
Published on: March 12, 2014
The SCFSlimb E3 ligase complex regulates asymmetric division to inhibit neuroblast overgrowth
Song Li1, Cheng Wang, Edwin Sandanaraj
1Neuroscience & Behavioral Disorders Program, Duke-National University of Singapore Graduate Medical School Singapore, Singapore City, Singapore.
Abstract:
Drosophila larval brain neuroblasts divide asymmetrically to balance between self-renewal and differentiation. Here, we demonstrate that the SCF(Slimb) E3 ubiquitin ligase complex, which is composed of Cul1, SkpA, Roc1a and the F-box protein Supernumerary limbs (Slimb), inhibits ectopic neuroblast formation and regulates asymmetric division of neuroblasts. Hyperactivation of Akt leads to similar neuroblast overgrowth and defects in asymmetric division. Slimb associates with Akt in a protein complex, and SCF(S)(limb) acts through SAK and Akt to inhibit neuroblast overgrowth. Moreover, Beta-transducin repeat containing, the human ortholog of Slimb, is frequently deleted in highly aggressive gliomas, suggesting a conserved tumor suppressor-like function.
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