Related Experiment Video
Updated: May 4, 2026

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
Incidence of acute cardiorenal syndrome type 3 in India
1Division of Nephrology, Department of Medicine, Adichunchanagiri Institute of Medical Sciences, B G Nagara, Karnataka, India. dr_pavanm@yahoo.co.in.
Insights
Acute renocardiac syndrome, a complication of acute kidney injury, affects 29% of patients in India. This condition significantly increases morbidity and mortality, necessitating early intervention.
Area of Science:
- Nephrology
- Cardiology
- Internal Medicine
Background:
- Acute renocardiac syndrome (cardiorenal syndrome type 3) is a critical condition.
- Its incidence and outcomes in Indian suburban populations remain understudied.
Purpose of the Study:
- To determine the incidence of acute renocardiac syndrome.
- To evaluate the outcomes of this syndrome in a specific Indian population.
Main Methods:
- An observational study was conducted.
- 100 patients admitted with acute kidney injury were assessed.
Main Results:
- Acute renocardiac syndrome was identified in 29% of patients.
- Acute gastroenteritis was the primary cause of acute kidney injury (46%).
- Cardiogenic pulmonary edema was the most frequent cause of cardiac dysfunction (56%).
- Only 42% of affected patients achieved full kidney function recovery.
- Renal replacement therapy was required by 43% of patients with acute renocardiac syndrome, compared to 9% without.
- Mortality rate was high at 17% in patients with acute renocardiac syndrome.
Conclusions:
- Acute renocardiac syndrome occurs with high incidence in this population.
- The syndrome is linked to substantial increases in morbidity and mortality.
- There is a critical need for widespread primordial prevention and prompt medical intervention.
Introduction:
The aim of this study was to determine the incidence of acute renocardiac syndrome (cardiorenal syndrome type 3) and its outcome in a suburban population in India.
Materials And Methods:
In an observational study, 100 patients admitted with acute kidney injury were evaluated.
Results:
Acute renocardiac syndrome was documented in 29%. Acute gastroenteritis (46%) was the leading cause of acute kidney injury. Cardiogenic pulmonary edema (56%) was the most common cause of acute cardiac dysfunction. Only 42% of the patients with acute renocardiac syndrome had complete recovery of kidney function. Requirement of renal replacement therapy was found to be significantly high in patients with acute renocardiac syndrome (43% versus 9% in those with AKI and no cardiorenal syndrome) and was associated with high rate of mortality (17%).
Conclusions:
This study shows that the incidence of acute renocardiac syndrome is high and is associated with increased morbidity and mortality. Hence, there is a need for primordial prevention and early intervention on large scale.
Related Concept Videos
Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury I: Introduction
Cardiac Catheterization I: Pre-Procedure Overview
Acute Kidney Injury II: Pathophysiology
Acute Kidney Injury V: Interprofessional Care

