Related Experiment Video
Updated: Jul 10, 2026

An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation
Published on: June 30, 2015
Pituitary follicular cells produce basic fibroblast growth factor
Abstract:
Cultured monolayers of bovine pituitary follicular cells, which transport ions, contain high amounts of mitogenic activity for endothelial cells which, on the basis of gene expression analysis, heparin-Sepharose elution profile, bioassay, immunoblotting, radioimmunoassay, and radioreceptor assay, has been identified as basic fibroblast growth factor (bFGF). These data indicate that follicular cells may be a major source of bFGF in the pituitary gland. Considering that bFGF has been proposed to play a role in paracrine regulation of pituitary hormone secretion, the data also suggest that these cells may exert important local regulatory functions.
Related Concept Videos
Regulation of Hematopoietic Stem Cells
Introduction to Fibroblasts
Multipotency and Niche of Bulge Stem Cell
Hormones of the Pituitary Gland
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
Folliculogenesis

