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Related Concept Videos

Role of Septins01:02

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Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
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Septins are protein filaments forming the cytoskeleton along with the microtubules, microfilaments, intermediate filaments, and other accessory proteins. In 1971 while studying the cell division cycle in mutant Saccharomyces cerevisiae Harwell et al. first identified the septin-related genes playing a crucial role in yeast cytokinesis. Fluorescence microscopy revealed that these proteins localize at the budding neck as rings. These ring-like proteins were then named Septins by John Pringle, and...
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Related Experiment Video

Updated: May 4, 2026

Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation
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Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation

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Septal reshaping

Antonio Maria Calafiore1, Michele Di Mauro, Angela Lorena Iacò

  • 1Division of Cardiac Surgery, University Hospital "S. Giovanni Battista", c.so Bramante 86, Turin, Italy.

Multimedia Manual of Cardiothoracic Surgery : MMCTS
|January 14, 2014
PubMed
Summary
This summary is machine-generated.

A novel surgical technique effectively repairs left ventricular aneurysms following myocardial infarction. This procedure improves heart function and reduces mitral regurgitation, offering good midterm outcomes for patients with septal scarring.

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Area of Science:

  • Cardiovascular Surgery
  • Cardiac Reconstruction
  • Myocardial Infarction Complications

Background:

  • Left ventricular (LV) aneurysm is a serious complication of acute myocardial infarction (AMI).
  • Traditional surgical approaches may have limitations, particularly when the postinfarctual scar predominantly involves the septum.

Purpose of the Study:

  • To describe and evaluate a new surgical technique for left ventricular aneurysm repair.
  • To assess the safety and efficacy of this technique, focusing on midterm outcomes.

Main Methods:

  • A novel surgical approach involving an apical incision directed towards the heart base.
  • Septal reconstruction using internal U-stitches to connect the anterior wall and septum.
  • Augmentation with an oval Dacron patch sutured from the septum to the anterior wall up to the new apex.

Main Results:

  • Low 30-day mortality rate.
  • Significant improvement in New York Heart Association (NYHA) class from 2.7±0.9 to 1.6±0.5 (P≪0.001).
  • Significant reduction in mitral regurgitation from 2.5 to 0.6, with no new cases developing. Significant reduction in LV end-diastolic and end-systolic volumes. Stroke volume normalized and ejection fraction increased.

Conclusions:

  • This new surgical technique provides a promising option for left ventricular aneurysm repair, especially in cases with significant septal involvement.
  • The procedure demonstrates favorable midterm results, including improved functional class and reduced mitral regurgitation.
  • The technique is associated with low mortality and good hemodynamic improvements.