C1-esterase inhibitor in early septicemia

In bacteremic pigs, both administered human C1INH and endogenous C1INH lost inhibitory activity. In septic pigs which received human C1INH a difference between immunologically determined concentration and inhibitory activity of C1INH became apparent. In animals which survived at least 24 hrs the C1INH activity showed an acute phase response. In a model of E. coli bacteremia in weaned pigs administration of human C1INH showed protective effects on lung capillary permeability as well as less leucocytosis.