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C1-esterase inhibitor in early septicemia
Progress in Clinical and Biological Research
|January 1, 1987
Summary
Human C1 inhibitor (C1INH) lost activity in septic pigs. However, administered C1INH protected against lung capillary permeability and reduced white blood cell counts in a swine sepsis model.
Area of Science:
- Immunology
- Veterinary Medicine
- Biochemistry
Background:
- Sepsis can lead to the loss of inhibitory activity in complement system proteins like C1 inhibitor (C1INH).
- Understanding C1INH behavior during sepsis is crucial for developing effective treatments.
Purpose of the Study:
- To investigate the activity and protective effects of human C1INH in a swine model of bacteremia and sepsis.
- To assess changes in C1INH concentration versus its inhibitory function in septic conditions.
Main Methods:
- Administered human C1INH to bacteremic pigs.
- Measured C1INH concentration and inhibitory activity.
- Evaluated lung capillary permeability and white blood cell (leukocyte) counts.
- Observed C1INH activity in pigs surviving at least 24 hours.
Main Results:
- Both endogenous and administered human C1INH lost inhibitory activity in bacteremic pigs.
- A discrepancy between C1INH concentration and activity was observed in septic pigs receiving human C1INH.
- Surviving animals exhibited an acute phase response in C1INH activity.
- Human C1INH administration reduced lung capillary permeability and leukocytosis in an E. coli bacteremia model.
Conclusions:
- Human C1INH can lose inhibitory function during sepsis in pigs.
- Despite activity loss, administered C1INH demonstrated protective effects in a swine sepsis model.
- C1INH activity changes during sepsis may involve an acute phase response.