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Urinary MCP-1/creatinine in Henoch-Schönlein purpura and its relationship with nephritis

Yolanda Fuentes1, Ana María Hernández, Pilar García-Roca

  • 1Laboratorio de Investigación en Nefrología, Hospital Infantil de México Federico Gómez, Calle Dr. Márquez 162, Col. Doctores, Deleg. Cuauhtémoc, C. P. 06720, México, D. F., México, fuvy76@hotmail.com.

Pediatric Nephrology (Berlin, Germany)
|January 14, 2014
PubMed
Abstract

Insights

Urinary monocyte chemotactic protein-1 (MCP-1) levels are higher in children with Henoch-Schönlein purpura (HSP) nephritis. Elevated MCP-1/creatinine can indicate severe kidney lesions and serve as an early biomarker for HSP nephritis.

Area of Science:

  • Pediatric Nephrology
  • Immunology
  • Biomarker Discovery

Background:

  • Monocyte chemotactic protein-1 (MCP-1) is implicated in macrophage and monocyte infiltration during early Henoch-Schönlein purpura (HSP) nephritis.
  • Understanding MCP-1's role is crucial for diagnosing and assessing the severity of HSP nephritis in children.

Purpose of the Study:

  • To compare urinary MCP-1/creatinine levels in children with and without HSP nephritis.
  • To determine if urinary MCP-1/creatinine levels correlate with the severity of renal lesions in HSP.

Main Methods:

  • Study included 77 children with HSP and 25 healthy controls.
  • Assessed serum creatinine, urinalysis, and 12-h proteinuria.
  • Quantified urinary MCP-1 levels using ELISA and calculated MCP-1/creatinine ratios.

Main Results:

  • Urinary MCP-1/creatinine levels were significantly elevated in children with HSP nephritis (median, 653 pg/mg) compared to those without nephritis (269 pg/mg) and healthy controls (191 pg/mg).
  • Patients with renal biopsies showed higher MCP-1/creatinine levels (1,412 pg/mg) than those without (302 pg/mg).
  • A urinary MCP-1 cut-off of 530 pg/mg demonstrated 81% sensitivity and 77% specificity for identifying patients requiring renal biopsy.

Conclusions:

  • Urinary MCP-1/creatinine levels are elevated in early-stage severe HSP nephritis.
  • Urinary MCP-1/creatinine serves as a potential non-invasive biomarker for identifying severe HSP nephritis and guiding renal biopsy decisions.

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