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Diffusional kurtosis imaging analysis in patients with hypertension.
Keigo Shimoji1, Takanori Uka, Yoshifumi Tamura
1Department of Radiology, National Center of Neurology and Psychiatry Hospital, Kodaira, Tokyo, 187-8551, Japan, kshimoji@ncnp.go.jp.
Hypertension is linked to white matter changes in middle-aged men, detectable with diffusional kurtosis imaging (DKI). This imaging technique may help screen for cerebrovascular disease risk before symptoms appear.
Area of Science:
- Neuroimaging
- Cardiovascular Health
- Medical Diagnostics
Background:
- Hypertension significantly contributes to morbidity in Japan.
- Early detection of hypertension-related complications is crucial for patient outcomes.
Purpose of the Study:
- To investigate the association between hypertension and white matter microstructural changes.
- To evaluate the utility of diffusional kurtosis imaging (DKI) in detecting these changes.
Main Methods:
- Utilized DKI-based whole-brain analysis in 15 hypertensive and 11 normotensive middle-aged men.
- Employed Pearson's correlation coefficient to assess relationships between blood pressure and white matter changes.
Main Results:
- Hypertensive participants exhibited significantly higher mean diffusional kurtosis (MDK) values compared to controls.
- Widespread white matter microstructural alterations were indicated by elevated MDK.
- A positive correlation was found between systolic/diastolic blood pressure and whole-brain MDK values.
Conclusions:
- Hypertension is associated with microstructural white matter changes in middle-aged men, preceding overt cerebrovascular disease.
- DKI shows potential as a screening tool for cerebrovascular disease risk in hypertensive individuals.
- Further research is needed to fully understand the relationship between hypertension and brain DKI.
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