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Aversion substance(s) of the rat coagulating glands
A M Gawienowski1, I J Berry, J J Kennelly
1Department of Biochemistry Department of Wildlife and Fisheries, University of Massachusetts, 01003, Amherst, Massachusetts.
Journal of Chemical Ecology
|January 14, 2014
Summary
Male rat urine contains aversion compounds linked to androgens. These substances disappear after castration or coagulating gland removal, but reappear with androgen therapy, indicating their crucial role.
Area of Science:
- Reproductive biology
- Animal behavior
- Endocrinology
Background:
- Adult male rat urine contains specific aversive substances.
- The origin and regulation of these compounds are not fully understood.
Purpose of the Study:
- To investigate the role of androgens and coagulating glands in the production of aversive substances in male rat urine.
Main Methods:
- Comparison of urine from intact adult males, castrated males, and males with removed coagulating glands.
- Assessment of urine aversiveness in relation to androgen treatment.
Main Results:
- Aversive substances were absent in urine from castrated rats.
- Removal of coagulating glands led to the loss of these aversion compounds.
- Androgen treatment restored the aversive substances in the urine of castrated rats.
Conclusions:
- Androgens are essential for the production of aversive substances in male rat urine.
- The coagulating glands play a critical role in the synthesis or secretion of these compounds.
- These findings highlight the hormonal regulation of chemical communication in rats.
