New treatments for bladder cancer: when will we make progress?
1Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans Street, Baltimore, MD, 21231, USA.
Current Treatment Options in Oncology
|January 14, 2014
Summary
Metastatic urothelial carcinoma has a poor prognosis. Emerging targeted therapies, like everolimus for TSC1 mutations, show promise for expanding future urothelial cancer treatment options.
Area of Science:
- Oncology
- Genetics
- Pharmacology
Background:
- Metastatic urothelial carcinoma (mUC) has a poor prognosis.
- Current treatments include chemotherapy (gemcitabine/cisplatin, M-VAC) and vinflunine (second-line in Europe).
- mUC harbors genetic alterations amenable to targeted therapies.
Purpose of the Study:
- To review the current landscape of targeted therapies for urothelial carcinoma.
- To highlight emerging targeted agents and their potential impact on mUC treatment.
- To discuss the future outlook for precision medicine in urothelial cancers.
Main Methods:
- Literature review of clinical trials and research on targeted therapies in urothelial carcinoma.
- Analysis of genetic alterations and their corresponding targeted drug candidates.
- Evaluation of early clinical findings for novel agents in mUC.
Main Results:
- Several targeted therapies are under clinical evaluation for urothelial cancers.
- Everolimus demonstrated activity in mUC patients with TSC1 mutations.
- No targeted therapies are currently approved for clinical use in urothelial cancers.
Conclusions:
- Targeted therapies represent a promising future direction for mUC treatment.
- Identifying relevant drug targets and patient subgroups is crucial for therapeutic success.
- The therapeutic arsenal for urothelial cancers is expected to expand with continued research.
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