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Updated: Jan 25, 2026

Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes

Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes

Published on: February 8, 2018

Photoacoustic Microscopy.

Junjie Yao¹, Lihong V Wang¹

¹Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.

Laser & Photonics Reviews

|January 14, 2014

Summary

This summary is machine-generated.

Photoacoustic microscopy (PAM) offers high-resolution in vivo imaging beyond optical diffusion limits. This hybrid technique provides versatile contrast for anatomical, functional, and molecular imaging in biomedical studies.

Keywords:

Photoacoustic microscopy blood flow imaging brain imaging functional imaging gene expression imaging metabolic imaging molecular imaging multi-scale imaging nanoparticle imaging real-time imaging tumor imaging

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Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes

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Three-dimensional Optical-resolution Photoacoustic Microscopy

Three-dimensional Optical-resolution Photoacoustic Microscopy

Published on: May 3, 2011

Area of Science:

Biomedical Imaging
Optoacoustic Imaging
Microscopy

Background:

Photoacoustic microscopy (PAM) is a hybrid in vivo imaging technique.
It detects optical contrast via the photoacoustic effect, overcoming the optical diffusion limit (~1 mm).
PAM offers scalability for high-resolution imaging at depths up to a few millimeters.

Purpose of the Study:

To review state-of-the-art developments in PAM.
To discuss key features of PAM implementations.
To highlight applications of PAM in biomedical studies.

Main Methods:

PAM utilizes the photoacoustic effect for acoustic detection of optical contrast.
It leverages weak acoustic scattering in tissue.
PAM provides absorption contrast, unlike scattering-based methods.

Main Results:

PAM surpasses the optical diffusion limit for deeper imaging.
It offers superior molecular imaging capabilities compared to fluorescence-based methods.
PAM enables simultaneous imaging of anatomical, functional, molecular, flow dynamic, and metabolic contrasts.

Conclusions:

PAM is a powerful in vivo imaging tool with broad biomedical applications.
Its ability to provide multimodal contrast enhances diagnostic and research capabilities.
Further developments in PAM promise significant advancements in biological and medical research.