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Published on: July 30, 2012
A subretinal neovascular membrane as a complication of endogenous Candida endophthalmitis
Abstract:
A 21-year-old woman developed endophthalmitis and a macular chorioretinal lesion secondarily to a Candida infection. She had been receiving intensive systemic antibiotic and steroid therapy for pelvic inflammatory disease. Blood cultures confirmed a Candida albicans septicemia, and amphotericin B was administered intravenously. As the eye inflammation resolved, healing of the chorioretinal lesion was complicated by the development of a subretinal neovascular membrane. The authors hypothesize that the formation of the membrane was related to an inflammatory alteration of the pigment epithelium--Bruch's membrane--choriocapillaris complex. To the authors' knowledge, this is the first such report following a Candida infection of the eye.
Insights
A Candida infection caused endophthalmitis and a macular lesion in a young woman. Healing led to a subretinal neovascular membrane, possibly due to inflammatory changes in the eye's inner layers.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Medical Mycology
Background:
- Endophthalmitis is a severe intraocular inflammation, often caused by microbial infections.
- Candida species are a significant cause of fungal endophthalmitis, particularly in immunocompromised individuals or those with systemic infections.
- Ocular inflammatory conditions can sometimes lead to secondary complications affecting retinal structures.
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