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The Impact of Left Ventricular Hypertrophy and Diastolic Dysfunction on Outcome in Intracerebral Hemorrhage Patients

Karen C Albright1, Joshua M Burak2, Tiffany R Chang3

  • 1Health Services and Outcomes Research Center for Outcome and Effectiveness Research and Education (COERE), University of Alabama at Birmingham, Birmingham, AL 35294-4410, USA ; Center of Excellence in Comparative Effectiveness Research for Eliminating Disparities (CERED) Minority Health & Health Disparities Research Center (MHRC), University of Alabama at Birmingham, Birmingham, AL 35294-4410, USA ; School of Public Health, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA.

ISRN Stroke
|January 14, 2014
PubMed

Insights

Left ventricular hypertrophy (LVH) and diastolic dysfunction (DD) were studied in patients with deep intracerebral hemorrhage (ICH). LVH and DD did not predict ICH volume, expansion, or poor outcomes, though LVH was linked to IVH.

Area of Science:

  • Neurology
  • Cardiology
  • Radiology

Background:

  • Deep intracerebral hemorrhage (ICH) is a significant cause of neurological deficit.
  • Left ventricular hypertrophy (LVH) and diastolic dysfunction (DD) are common cardiovascular conditions.
  • The relationship between cardiac abnormalities and ICH outcomes requires further elucidation.

Purpose of the Study:

  • To determine the prevalence of LVH and DD in patients with supratentorial deep ICH.
  • To assess if LVH or DD independently predict initial ICH volume, hematoma expansion, or poor outcomes.

Main Methods:

  • Cross-sectional study of ICH patients (7/2008-12/2010).
  • Exclusion criteria included traumatic, lobar, infratentorial ICH, elevated INR, structural malformations, or prior surgery.
  • Logistic and linear regressions analyzed LVH/DD as predictors of ICH characteristics and outcomes.

Main Results:

  • LVH was not a significant independent predictor of initial ICH volume (P=0.344) or 33% volume expansion (P=0.378) after adjusting for hemostatic agents.
  • LVH was not a significant independent predictor of poor functional outcome (P=0.778) after adjusting for age, infections, and hemostatic agents.
  • Similar non-significant findings were observed for DD.

Conclusions:

  • In patients with deep ICH, LVH was associated with a higher likelihood of developing intraventricular hemorrhage (IVH).
  • LVH was not found to be an independent predictor of initial ICH volume, hematoma expansion, or poor short-term functional outcomes.
  • Diastolic dysfunction (DD) also did not independently predict these adverse ICH-related events.
Abstract

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