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Updated: May 4, 2026
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
[Treatment of relapses of multiple sclerosis (a review)]
Abstract:
The most common clinical type of multiple sclerosis (MS), affecting up to 85% of patients living with this disease, is relapsing remitting(RRMS). Relapses are associated with significant functional impairment and decreased quality of life. Residual symptoms after MS relapses may persist and lead to sustained disability. Adequate management of MS relapses may help to shorten and lessen the symptoms and disability associated with their course. Systemic corticosteroids and adrenocorticotropic hormone (ACTH) have broad regulatory approval and remain the most established and validated treatment options for MS relapses. Recently, the direct anti-inflammatory effects and immunomodulatory activity of ACTH have been shown. Algorithms of using these medications for MS relapse treatment, data on plasmapheresis and perspectives of other therapeutic methods are reviewed.
Insights
Relapsing remitting multiple sclerosis (RRMS) management focuses on shortening relapse symptoms and disability. Established treatments like corticosteroids and adrenocorticotropic hormone (ACTH) are reviewed, alongside emerging therapies.
Area of Science:
- Neurology
- Immunology
Context:
- Relapsing remitting multiple sclerosis (RRMS) affects up to 85% of patients.
- MS relapses cause significant functional impairment and reduced quality of life.
- Persistent symptoms post-relapse can lead to long-term disability.
Purpose:
- To review current management strategies for multiple sclerosis relapses.
- To discuss the role of systemic corticosteroids and adrenocorticotropic hormone (ACTH) in treating MS relapses.
- To explore emerging therapeutic perspectives for MS relapse management.
Summary:
- Systemic corticosteroids and ACTH are the most validated treatments for MS relapses.
- Recent research highlights the direct anti-inflammatory and immunomodulatory effects of ACTH.
- The review covers treatment algorithms, plasmapheresis data, and other therapeutic options.
Impact:
- Optimizing MS relapse management can reduce symptom duration and severity.
- Understanding ACTH's mechanisms may lead to more targeted therapies.
- This review provides a comprehensive overview for clinicians managing MS patients.
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