Related Experiment Video

Updated: May 4, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.8K

Molecular regulation of cholesterol metabolism: HDL-based intervention through drugs and diet

Amit Kumar Rai1, Patrizia Debetto1, Federica Dabbeni Sala1

  • 1Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo E. Meneghetti, 2, 35131 Padova, Italy.

Indian Journal of Experimental Biology
|January 15, 2014
PubMed

Insights

New strategies targeting cholesterol metabolism, including pharmacological and nutritional approaches, show promise for cardiovascular disease treatment. Natural products offer a low-cost, safe alternative to traditional drugs.

Area of Science:

  • Cardiovascular Science
  • Metabolic Research
  • Pharmacology

Background:

  • Arterial cholesterol overload is a primary driver of cardiovascular diseases.
  • Current anticholesterolemic drugs have limitations in efficacy and adverse effects.

Purpose of the Study:

  • To review innovative pharmacological and nutritional strategies for cholesterol metabolism control.
  • To analyze emerging therapeutic interventions for cardiovascular disease.

Main Methods:

  • Review of current research on pharmacological interventions targeting high-density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT).
  • Analysis of nutritional interventions including fibers, phytosterols, and probiotics influencing cholesterol absorption and RCT.
  • Examination of genetic control, receptor agonism, and protein inhibition in pharmacological approaches.

Main Results:

  • Pharmacological strategies involve targeting apolipoprotein A-I (ApoA-I), liver X-receptor alpha (LXRalpha), cholesteryl ester transport protein (CETP), scavenger receptor BI (SR-BI), and ecto F0F1ATPase/synthase.
  • Nutritional interventions focus on modulating cholesterol absorption and reabsorption via fibers, phytosterols, and probiotics, impacting the final steps of RCT.
  • Emerging biotechnological research is yielding promising probiotics, fibers, and phytosterols.

Conclusions:

  • Innovative pharmacological and nutritional strategies offer new therapeutic avenues for managing cholesterol metabolism.
  • Natural products like probiotics, fibers, and phytosterols present advantages of reduced adverse effects and lower cost compared to traditional drugs.
  • While new drug development is ongoing, natural interventions are nearing clinical readiness.

More Related Videos

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

13.2K
Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

5.6K

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.7K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
2.1K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
741
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
121
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
890
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
2.5K