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Related Experiment Videos

Nondependent monkeys self-administer hydromorphone.

J W Ternes, R N Ehrman, C P O'Brien

    Behavioral Neuroscience
    |June 1, 1985
    PubMed
    Summary
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    Hydromorphone (HYM) self-administration was acquired by monkeys, suggesting its reinforcing properties are sufficient for opioid intake. Tolerance and physical dependence were not necessary for HYM self-administration in this study.

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Behavioral Science

    Background:

    • Opioid self-administration is a key factor in addiction.
    • Understanding the reinforcing properties of opioids is crucial for developing effective treatments.

    Purpose of the Study:

    • To investigate whether the positive reinforcing properties of hydromorphone (HYM) are sufficient to maintain self-administration in non-human primates.
    • To assess the development of tolerance and physical dependence to HYM during self-administration.

    Main Methods:

    • Monkeys were trained to self-administer cocaine and then hydromorphone (HYM) under a fixed-ratio schedule.
    • HYM self-maintenance sessions were conducted, followed by assessments for spontaneous and precipitated withdrawal using naloxone.
    • Tolerance was evaluated by administering a HYM challenge dose.

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    Main Results:

    • All monkeys acquired both cocaine and HYM self-administration.
    • No spontaneous withdrawal or disruption of appetitive responding was observed.
    • Naloxone precipitated withdrawal in rhesus monkeys but not cynomolgus monkeys.
    • A HYM challenge dose suppressed food-related responding, indicating a lack of tolerance.

    Conclusions:

    • The positive reinforcing effects of hydromorphone (HYM) are sufficient to maintain opioid self-administration.
    • Tolerance and physical dependence are not necessary for HYM self-administration.
    • Species differences in naloxone-precipitated withdrawal were observed.