Related Experiment Video
Updated: May 4, 2026

Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts
Published on: April 13, 2022
Bis (histidine) with N2 vehicle: an important skeleton for MR/chelation therapy
Pooja Srivastava1, Anjani K Tiwari, Dipti Kakkar Thukral
1Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Brig. S. K. Mazumdar Road, Delhi, 110054, India.
Abstract:
Bis (histidine) ethylenediamine tetraacetic acid, EDTA-bis (amide) analog, has been synthesized starting from with EDTA bis-anhydride and protected histidine and evaluated in vitro as an important agent for MR and chelation therapy. The kinetic inertness of compound was analyzed by the exchange reactions with the essential metals of human body. The stability and protonation constants of the complexes formed between the ligand and M(3+) and M(2+) have been determined by pH potentiometry and spectrophotometry at 25 °C and constant ionic strength maintained with 0.10 m KCl. The in vivo stability and metabolite profile were confirmed in plasma and serum.
More Related Videos
12:59A Study of the Complexation of MercuryII with Dicysteinyl Tetrapeptides by Electrospray Ionization Mass Spectrometry
Published on: January 8, 2016
09:08Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method
Published on: December 20, 2024
Related Concept Videos
Phase II Reactions: Miscellaneous Conjugation Reactions
A key example involves the conjugation of cyanide ions, which impair cellular respiration and alter hemoglobin into non-oxygen-carrying cyanmethemoglobin. To neutralize this threat, a sulfur atom from thiosulphate is transferred to the cyanide ion, catalyzed by the enzyme rhodanese, resulting in an inactive compound called thiocyanate. The production of...
EDTA: Chemistry and Properties
Complexation Equilibria: The Chelate Effect
Amines to Sulfonamides: The Hinsberg Test
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing sulfonyl...