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Related Experiment Video

Updated: May 4, 2026

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Regulation of adiponectin multimerization, signaling and function.

Meilian Liu1, Feng Liu1

  • 1Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Second Xiangya Hospital, Metabolic Syndrome Research Center and Diabetes Center, Institute of Aging and Geriatric Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Hunan, China.

Best Practice & Research. Clinical Endocrinology & Metabolism
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PubMed
Summary

Adiponectin

Keywords:
DsbA-LER stressadiponectinadiponectin multimerizationadiponectin multimers

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Metabolic Research

Background:

  • Adiponectin, a key metabolic hormone, circulates in serum as distinct multimers (trimer, hexamer, high molecular weight).
  • These adiponectin complexes possess significant insulin-sensitizing, anti-inflammatory, and anti-diabetic properties.
  • Different adiponectin forms activate specific signaling pathways and exert tissue-specific functions.

Purpose of the Study:

  • To review mechanisms regulating adiponectin multimerization.
  • To describe target tissues for distinct adiponectin multimers.
  • To discuss the role of endoplasmic reticulum and mitochondrial stress in diet-induced adiponectin downregulation.

Main Methods:

  • Literature review of adiponectin multimerization.
  • Analysis of adiponectin complex functions in target tissues.
  • Discussion of stress-related pathways affecting adiponectin levels.

Main Results:

  • Adiponectin multimerization is tightly regulated.
  • Distinct adiponectin complexes have specific tissue targets and functions.
  • Endoplasmic reticulum and mitochondrial stress can downregulate adiponectin, particularly in diet-induced conditions.

Conclusions:

  • Disulfide bond A oxidoreductase-like protein (DsbA-L) may prevent endoplasmic reticulum stress.
  • DsbA-L promotes adiponectin multimerization, stability, and function.
  • Understanding adiponectin regulation is crucial for metabolic disease research.