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Adiponectin effects on the kidney.

Natalie Sweiss1, Kumar Sharma1

  • 1Center for Renal Translational Medicine, Institute of Metabolomic Medicine, Division of Nephrology-Hypertension, Department of Medicine, University of California, San Diego and VA Medical Center La Jolla, 9500 Gilman Drive, MC 0711, La Jolla, CA 92093, USA.

Best Practice & Research. Clinical Endocrinology & Metabolism
|January 15, 2014
PubMed
Summary
This summary is machine-generated.

Adiponectin, a hormone from fat tissue, impacts kidney disease. While low levels link to obesity-related kidney issues, high levels in chronic kidney disease predict its worsening.

Keywords:
AMP-activated protein kinaseadipokinesadiponectinalbuminuriakidney diseaseobesityoxidant stressproteinuria

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Area of Science:

  • Endocrinology
  • Nephrology
  • Metabolic Syndrome

Background:

  • Adiponectin is a key hormone secreted by adipose tissue.
  • Altered adiponectin levels are implicated in obesity, insulin resistance, and cardiovascular disease.
  • Obesity-related kidney disease encompasses conditions like microalbuminuria and focal segmental glomerulosclerosis.

Purpose of the Study:

  • To explore the dual role of adiponectin in kidney disease progression.
  • To investigate the mechanisms linking adiponectin to kidney dysfunction.
  • To highlight the increasing prevalence of obesity-related chronic kidney disease.

Main Methods:

  • Review of existing literature on adiponectin and kidney disease.
  • Analysis of correlations between adiponectin levels and kidney disease markers.
  • Exploration of proposed molecular pathways involving adiponectin, AMPK, and NADPH oxidase.

Main Results:

  • Reduced adiponectin is associated with obesity-related kidney disease and early diabetic nephropathy.
  • Elevated adiponectin levels in established chronic kidney disease (CKD) predict disease progression.
  • The adiponectin-AMPK-NADPH oxidase pathway is implicated in kidney function.

Conclusions:

  • Adiponectin exhibits a complex, context-dependent role in kidney health.
  • Understanding the adiponectin pathway is crucial for managing obesity-related CKD.
  • Further research is needed to target the adiponectin-AMPK-Nox pathway for therapeutic interventions in CKD.