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Published on: October 12, 2017
Correlation between the Xba I polymorphism of apoB gene and serum lipid profiles in Li ethnic group
Yue-Li Liu1, Yun-Bo Zhang2, Ying Li2
1School of Pharmacy, Hainan Medical College, Haikou 571101, P. R. China; Department of Cardiology, People's hospital of Sanya, Sanya 572000, P. R. China.
Objective:
To study correlation between the Xba I polymorphism of apoB gene and plasma lipid profiles in Li ethnic group.
Methods:
Total 151 cases of healthy Li people were recruited randomly by cluster sampling and 200 Han people were recruited as control; blood was drawn to analyze Xba I polymorphism distribution of apoB gene and serum lipid levels.
Results:
There were lower serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels in serum of Li people; while, high density lipoprotein cholesterol (HDL-C), X-/X+ genotype and X+ allele frequencies exhibited higher levels than Han people. Interestingly, HDL-C level was reduced, while LDL-C level was enhanced in subjects carrying heterozygous (X-/X+) genotype compared to homozygous (X-/X-) genotype. Additionally, there were no difference in serum level of triglyceride, TC, apoprotein A (apo A) and apoprotein B (apo B) between Li and Han people, the same results were showed between X-/X+ and X-/X- genotype carriers.
Conclusions:
Xba I polymorphism of apoB gene is correlated to the profiles of serum lipid level, X-/X+ genotype carriers are phenotyped with higher LDL-C level and lower level of HDL-C in Li ethnic group.
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