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Updated: Aug 8, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
Published on: June 6, 2011
Resuscitation in haemorrhagic shock--pulmonary and renal effects: an adverse effect of stabilised plasma protein
Abstract:
In a model of severe canine haemorrhagic shock, greyhound dogs were randomly allocated to resuscitation with 0.9% saline, polygelin, hetastarch, or stabilised plasma protein solution (SPPS). Resuscitation was continued back to baseline pulmonary artery wedge pressure, and extravascular lung water (EVLW) and urine output were measured. EVLW following resuscitation was higher in the saline group than in any of the three colloid groups. Urine output following resuscitation was significantly lower in the SPPS group than in any other group. The results suggest that SPPS has an adverse effect on renal function in this model.
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