A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons
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Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics
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Yu-Man Ho1, Ngan-Pan Bennett Au, Ka-Leung Wong
1Department of Biology & Chemistry, City University of Hong Kong, Tat Chee Ave., Kowloon, Hong Kong. eddiema@cityu.edu.hk bhmhwlam@cityu.edu.hk.
Chemical Communications (Cambridge, England)
|January 15, 2014
Abstract:
Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, {[Pt(L1)]2(μ-dppm)}(2+) (1) and {[Pt(L2)]2(μ-dppm)}(2+) (2), as lysosome-specific two-photon imaging probes.
