Does selenium matter in cardiometabolic disorders? A short review of the evidence
P Sabino1, S Stranges, P Strazzullo
1Department of Clinical Medicine and Surgery, ESH Excellence Center of Hypertension, Federico II University of Naples Medical School, Naples, Italy.
Abstract:
Selenium is an essential micronutrient in the human diet. It is a constituent of selenoproteins, linked to cysteine, and is involved in the defense against oxidative stress. Few studies suggested a role of selenoproteins in the prevention of chronic degenerative disorders, including Parkinson's and Alzheimer disease, cancer, cardiovascular disease, atherosclerosis, stroke, and infertility. On the other hand, concerns were raised about a possible association of selenium supplementation with increased risk of developing insulin resistance and Type 2 diabetes. The objective of this article is to briefly review the results of the observational (cohort and case-control) studies as well as of the randomized controlled trials of selenium supplementation and risk of metabolic and cardiovascular disorders.
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