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Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Related Experiment Video

Updated: May 4, 2026

A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells

A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells

Published on: May 17, 2021

Forgotten gems: human CD34(-) hematopoietic stem cells

Fernando Anjos-Afonso¹, Dominique Bonnet¹

¹Haematopoietic Stem Cell Lab; Cancer Research UK; London Research Institute; London, UK.

Cell Cycle (Georgetown, Tex.)

|January 15, 2014

Summary

No abstract available in PubMed .

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