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Evoked potentials and EEG in multiple sclerosis.

A Pakalnis, M E Drake, N Dadmehr

    Electroencephalography and Clinical Neurophysiology
    |October 1, 1987
    PubMed
    Summary
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    This study found that severe multiple sclerosis (MS) plaque disease on MRI and greater physical disability correlated with abnormal brain-stem auditory evoked potentials (BAEPs). Visual evoked potentials (VEPs) correlated only with MRI findings.

    Area of Science:

    • Neuroscience
    • Neurology
    • Medical Imaging

    Background:

    • Multiple sclerosis (MS) is a chronic demyelinating disease affecting the central nervous system.
    • Clinical presentation of MS varies widely, impacting physical function, cognition, and neurological status.
    • Objective measures are needed to correlate disease burden with clinical manifestations.

    Purpose of the Study:

    • To investigate the correlation between neuroimaging findings, evoked potentials, and clinical disability in patients with multiple sclerosis.
    • To assess the relationship between magnetic resonance imaging (MRI) findings, electroencephalogram (EEG), cerebrospinal fluid (CSF) analysis, and clinical outcomes like disability, dementia, and seizures.

    Main Methods:

    • Thirteen patients with clinically definite multiple sclerosis underwent electroencephalogram (EEG), magnetic resonance imaging (MRI), evoked potentials (brain-stem auditory evoked potentials - BAEPs, visual evoked potentials - VEPs), and cerebrospinal fluid (CSF) analysis.

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  • Clinical disability was assessed using the Kurtzke score.
  • Correlation analysis was performed between MRI plaque load, clinical scores, and electrophysiological findings.

    • Main Results:

    • Significant correlation observed between severe plaque disease on MRI and increased physical disability with abnormal brain-stem auditory evoked potentials (BAEPs).
    • Abnormalities in visual evoked potentials (VEPs) showed correlation solely with MRI findings.
    • Electroencephalogram (EEG) findings did not correlate with the assessed clinical parameters or MRI results.

    Conclusions:

    • Brain-stem auditory evoked potentials (BAEPs) appear sensitive to the extent of disease burden and physical disability in multiple sclerosis, likely reflecting corticospinal pathway involvement.
    • Visual evoked potentials (VEPs) are primarily associated with MRI-detectable lesions.
    • EEG is less informative in correlating with physical disability and MRI findings in this MS cohort.