Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

88
Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
88
Potentiometry: Membrane Electrodes01:15

Potentiometry: Membrane Electrodes

2.3K
Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at...
2.3K
Types of Signaling Molecules01:32

Types of Signaling Molecules

10.2K
In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...
10.2K
Bacterial Signaling01:30

Bacterial Signaling

29.8K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
29.8K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

4.7K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
4.7K
Signal Transduction: Overview01:26

Signal Transduction: Overview

8.6K
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gait Analysis After Reverse Total Shoulder Arthroplasty.

JB & JS open access·2026
Same author

Diagnostic Delay and Clinical Characteristics of Glomus Tumors in the Hand: A Case Series of 11 Patients.

Cureus·2026
Same author

Factors Associated With Kirschner Wire Backout After Tension Band Wiring for Olecranon Fractures: A Retrospective Study.

Cureus·2026
Same author

Fundamental characteristics of voltage-modulated helium plasma for multi-element analysis in low-volume samples.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry·2026
Same author

Open Reduction and Stabilization Without Internal Fixation for the Treatment of Displaced Radial Neck Fractures.

Cureus·2026
Same author

Mid-to long-term outcomes and CT-assessed radiolucency with cemented single-peg glenoid component for anatomic total shoulder arthroplasty.

Journal of orthopaedics·2025

Related Experiment Video

Updated: May 4, 2026

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
08:22

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

15.1K

Pore-forming compounds as signal transduction elements for highly sensitive biosensing.

Masao Sugawara1, Atsushi Shoji, Misato Sakamoto

  • 1Department of Chemistry, College of Humanities and Sciences, Nihon University.

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
|January 15, 2014
PubMed
Summary

This review highlights pore-forming compounds for sensitive biosensing. We explore their use in lipid bilayers and biomembranes for advanced molecular detection.

More Related Videos

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
10:07

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

1.5K
Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
07:07

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology

Published on: March 12, 2015

9.0K

Related Experiment Videos

Last Updated: May 4, 2026

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
08:22

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

15.1K
Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
10:07

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

1.5K
Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
07:07

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology

Published on: March 12, 2015

9.0K

Area of Science:

  • Biomolecular Engineering
  • Nanotechnology
  • Biosensing

Background:

  • Pore-forming compounds are crucial for signal transduction in biosensing.
  • Developing highly sensitive biosensing platforms is an ongoing challenge.

Purpose of the Study:

  • To review recent advances in designing molecular sensing interfaces using pore-forming compounds.
  • To present the potential applications of these compounds in various bilayer systems.

Main Methods:

  • Design and characterization of molecular sensing interfaces.
  • Incorporation of pore-forming compounds (gramicidin, MCM-41) into lipid bilayers.
  • Investigation of natural glutamate receptor channels in biomembranes.

Main Results:

  • Demonstrated the utility of pore-forming compounds in spherical and planar lipid bilayers.
  • Showcased the integration of gramicidin and MCM-41 for enhanced sensing capabilities.
  • Presented findings on natural glutamate receptor channels within biomembranes.

Conclusions:

  • Pore-forming compounds offer significant potential for developing highly sensitive biosensors.
  • Molecular sensing interfaces based on lipid bilayers and biomembranes are promising for advanced applications.
  • Further research into these systems can lead to novel diagnostic and analytical tools.