Decrease in cell free DNA levels following participation in stress reduction techniques among women undergoing
Johanna Czamanski-Cohen1, Orly Sarid, Julie Cwikel
1Center for Women's Health Studies and Promotion, the Spitzer Department of Social Work, Ben Gurion University of the Negev, Beer Sheva, Israel, 84105, johannac@bgu.ac.il.
Archives of Women'S Mental Health
|January 15, 2014
Summary
Practicing stress reduction techniques may lower plasma cell-free DNA (CFD) levels in women undergoing in vitro fertilization (IVF). Lower CFD levels were observed in women using stress reduction, potentially improving IVF outcomes.
Area of Science:
- Reproductive endocrinology and infertility research.
- Biomarker analysis in assisted reproductive technologies.
Background:
- Elevated plasma cell-free DNA (CFD) levels are associated with in vitro fertilization (IVF) failure.
- Stress is a common factor for women undergoing IVF and embryo transfer (ET).
Purpose of the Study:
- To investigate the impact of stress reduction techniques on plasma CFD levels in women undergoing IVF/ET.
- To determine if stress reduction influences a key biomarker linked to IVF success.
Main Methods:
- Pilot study involving 14 women with elevated baseline plasma CFD undergoing IVF/ET.
- Comparison of plasma CFD levels between women practicing stress reduction techniques and those who did not.
- Statistical analysis using Wilcoxon nonparametric tests and paired sample t-tests.
Main Results:
- Women practicing stress reduction techniques showed reduced plasma CFD levels.
- CFD levels in the stress reduction group decreased to non-elevated ranges.
- A significant decline in CFD was observed in participants using stress reduction methods.
Conclusions:
- Stress reduction techniques may lead to physiological changes that lower plasma CFD.
- Reducing plasma CFD through stress management could potentially improve IVF and embryo transfer success rates.
- Further research is warranted to confirm the efficacy of stress reduction in improving IVF outcomes.
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