Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Randomised controlled trial comparing antibiotic cement bead pouch versus negative pressure wound therapy for the management of severe open tibia fracture wounds: Beads versus VAC (BvV) protocol.

BMJ open·2026
Same author

Poor prognosis outcome tumors, bacteria-infected tumors and nanodrugs: current evidence and hypotheses towards a paradigm change for treatment.

Cancer biology & medicine·2026
Same author

The Enamel Organ Tissue Engineering Singularity of 2040.

The International journal of oral & maxillofacial implants·2026
Same author

Juvenile Chondrocyte Cell Sheet Layering Enhances In Vitro Chondrogenic Differentiation.

ACS biomaterials science & engineering·2026
Same author

Rapid podocyte loss in murine models triggers the formation of podocyte-parietal epithelial cell intercellular bridges.

American journal of physiology. Renal physiology·2026
Same author

<i>Fosl2</i> regulates the transition from parietal epithelial cells to myofibroblasts in the kidney.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: May 4, 2026

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
07:22

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Published on: March 28, 2013

38.4K

Metabolically active human brown adipose tissue derived stem cells.

Francisco J Silva1, Dolly J Holt, Vanessa Vargas

  • 1Department of Surgery, Division of Cardiothoracic Surgery, University of Utah, Salt Lake City, Utah, USA.

Stem Cells (Dayton, Ohio)
|January 15, 2014
PubMed
Summary

Researchers discovered active brown adipose tissue (BAT) stem cells in adult humans. These cells can be expanded and differentiated, offering a new target for treating obesity and metabolic disorders.

Keywords:
AdiposeBrown adipose tissueDiabetesObesityScaffoldsStem cells

More Related Videos

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice
04:46

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Published on: February 3, 2023

2.3K
Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

10.9K

Related Experiment Videos

Last Updated: May 4, 2026

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
07:22

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Published on: March 28, 2013

38.4K
Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice
04:46

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Published on: February 3, 2023

2.3K
Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

10.9K

Area of Science:

  • Metabolic research
  • Stem cell biology
  • Human physiology

Background:

  • Brown adipose tissue (BAT) is crucial for mammalian energy homeostasis and thermogenesis.
  • BAT was thought to involute in childhood, but active depots exist in adult humans.
  • Previous research identified stem cells in mice and differentiated human cells in vitro, but not multipotent BAT stem cells from adult human depots.

Purpose of the Study:

  • To identify and characterize a novel stem cell population within adult human brown adipose tissue.
  • To investigate the in vitro expansion and differentiation potential of these cells.
  • To establish a new cellular target for metabolic disorder therapies.

Main Methods:

  • Isolation of stem cells from adult human BAT depots.
  • In vitro expansion and characterization of the stem cell population.
  • Multilineage differentiation assays and functional assessment of brown adipocyte differentiation.

Main Results:

  • A clonogenic population of metabolically active BAT stem cells was identified in adult humans.
  • These stem cells demonstrated successful expansion in vitro.
  • The cells exhibited multilineage differentiation potential and could functionally differentiate into brown adipocytes.

Conclusions:

  • This study defines a novel, metabolically active stem cell population residing in adult human BAT.
  • These BAT-derived stem cells represent a promising target for therapeutic strategies aimed at restoring energy homeostasis.
  • Activation of these stem cells could lead to new treatments for obesity and related metabolic disorders.