Related Experiment Video

Updated: May 4, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

38.4K

Does treatment of psoriasis reduce the risk of cardiovascular disease?

Sarah Churton1, Liza Brown, Thuzar M Shin

  • 1Department of Dermatology, Murdough Family Center for Psoriasis, University Hospitals Case Medical Center, 11100 Euclid Ave. Bolwell 3100, Cleveland, OH, 44106, USA, sarah.churton@uhhospitals.org.

Drugs
|January 15, 2014
PubMed

Insights

Psoriasis patients face higher cardiovascular risks. Certain treatments, like methotrexate and TNF-α inhibitors, may improve heart health by reducing inflammation and cardiovascular events.

Area of Science:

  • Dermatology
  • Cardiology
  • Immunology

Background:

  • Psoriasis is an inflammatory condition linked to cardiovascular disease (CVD) and increased mortality.
  • Systemic inflammation may be a common pathway connecting psoriasis and CVD.
  • The impact of psoriasis treatments on cardiovascular outcomes remains unclear.

Purpose of the Study:

  • To review evidence on how psoriasis therapies affect cardiovascular biomarkers and risk.
  • To assess the cardiovascular safety and efficacy of various psoriasis treatments.

Main Methods:

  • Systematic review of 23 original research publications.
  • Analysis of studies examining psoriasis treatments and cardiovascular health indicators.

Main Results:

  • Phototherapy shows potential in reducing inflammatory cytokines but lacks strong evidence for decreased CVD outcomes.
  • Methotrexate and tumor necrosis factor-α inhibitors demonstrate improvements in cardiovascular inflammatory biomarkers and CVD outcomes.
  • Interleukin-12/23 inhibitors have varied short-term data, with no clear increase in cardiovascular events observed.

Conclusions:

  • Some psoriasis treatments may positively influence cardiovascular health.
  • Methotrexate and TNF-α inhibitors appear beneficial for cardiovascular risk in psoriasis patients.
  • Further research is needed to fully elucidate the cardiovascular effects of all psoriasis therapies.

More Related Videos

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

1.1K
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

3.6K

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
741
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
757
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
6.7K
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
890
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
655