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[Progress on neuroprotective effects of erythropoietin]
1Department of Neurology, The Second Affiliated Hospital,Medical College of Xi'an Jiaotong University, Xi'an 710004, China.
Abstract:
The function of erythropoietin (EPO) is recognized as a stimulator for proliferation of red blood cell (RBC), however,recent studies have showed that EPO and EPO-R are widely distributed in nervous system, which indicates that it may also have important functions in nervous system. Studies proved its neuroprotective effects, especially in ischemic-hypoxic nerve tissues. These effects are mainly activated through several signal transduction pathway downstream and multiple mechanisms are involved. As a neuroprotective factor, EPO has been investigated in the clinical studies, which may lead to the clinical application in the future.
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