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Sleep disorders and systemic lupus erythematosus
11Psychiatry Unit, University of Pisa, Pisa, Italy.
Lupus
|January 15, 2014
Summary
Sleep disorders affect over half of patients with systemic lupus erythematosus (SLE), often linked to disease activity, pain, and fatigue. Depression is a key suspected factor.
Area of Science:
- Rheumatology
- Sleep Medicine
- Psychiatry
Background:
- Sleep disturbances are common in rheumatic diseases like systemic lupus erythematosus (SLE).
- The prevalence and contributing factors of sleep disorders in SLE patients are not well understood.
Purpose of the Study:
- To review clinical and psychobiological data on the relationship between sleep disturbances and SLE.
- To synthesize current knowledge on sleep disorders in SLE patients.
Main Methods:
- Systematic literature search of MEDLINE, EMBASE, and PsychINFO.
- Used MeSH headings and keywords for "sleep disorders" and "SLE".
Main Results:
- Nine studies were included, reporting sleep disorder prevalence from 55% to 85%.
- Sleep disorders were associated with SLE disease activity, pain, and fatigue.
- Psychosocial factors, depression, steroid use, and inflammation were hypothesized contributing factors.
Conclusions:
- Sleep disorders are prevalent in over half of SLE patients and linked to disease activity.
- Pain and fatigue are significantly related to sleep disturbances in SLE.
- Psychosocial factors, particularly depression, are frequently implicated in the SLE-sleep disorder association.
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