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Updated: May 4, 2026

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HSF1 at a glance.

Anniina Vihervaara1, Lea Sistonen

  • 1Department of Biosciences, Åbo Akademi University, 20520 Turku, Finland.

Journal of Cell Science
|January 15, 2014
PubMed
Summary
This summary is machine-generated.

Heat shock factor 1 (HSF1) is a key regulator of cellular stress responses and homeostasis. Recent studies show HSF1 controls broader cellular processes beyond heat shock proteins, impacting metabolism, aging, and cancer.

Keywords:
Cancer progressionChromatin environmentHeat shock factorOrganismal stress responseProteostasisTranscription

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Heat shock factor 1 (HSF1) is a conserved transcription factor crucial for cellular homeostasis.
  • Its primary role involves transactivating heat shock protein (HSP) genes in response to stress.
  • Emerging evidence indicates HSF1's involvement in a wider array of cellular functions.

Purpose of the Study:

  • To review recent advancements in understanding HSF1.
  • To discuss the regulatory mechanisms controlling HSF1 activity.
  • To present the diverse physiological and pathological processes mediated by HSF1.

Main Methods:

  • Review of recent genome-wide studies.
  • Analysis of HSF1's role in various cellular contexts.
  • Discussion of organismal control mechanisms.

Main Results:

  • HSF1 reprogramming of transcription extends beyond HSPs.
  • HSF1 influences fundamental processes like metabolism, gametogenesis, and aging.
  • HSF1 plays a significant role in cancer progression.

Conclusions:

  • HSF1 is a central regulator with multifaceted roles in both normal physiology and disease.
  • Understanding HSF1's context-dependent functions is critical.
  • Further research into HSF1 regulation and pathways is warranted.