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EGFR controls IQGAP basolateral membrane localization and mitotic spindle orientation during epithelial morphogenesis

Inmaculada Bañón-Rodríguez1, Manuel Gálvez-Santisteban, Silvia Vergarajauregui

  • 1Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.

The EMBO Journal
|January 15, 2014
PubMed
Summary

Proper mitotic spindle orientation is crucial for epithelial tubule formation. A new study reveals IQGAP1 and epithelial growth factor receptor (EGFR) complex controls this process by anchoring IQGAP1 to the cell membrane, ensuring correct organ development.

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