Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The ABO Blood Group01:12

The ABO Blood Group

8.6K
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
8.6K
The ADP/ATP Carrier Protein01:42

The ADP/ATP Carrier Protein

3.6K
ADP/ATP carrier or AAC protein is the most abundant carrier protein in the inner mitochondrial membrane. It transports large quantities of ADP and ATP, equivalent to the average human body weight, every day. Among other transporters, ACC protein is one of the best-studied members of the mitochondrial carrier protein family. The ADP/ATP carrier protein comprises two transmembrane helices connected to a loop and a single alpha-helix on the matrix side. It switches between two conformational...
3.6K
ABC Transporters: Exporter01:31

ABC Transporters: Exporter

5.7K
ATP-binding cassette or ABC transporter is the largest superfamily of integral membrane proteins. The transporters have transmembrane-binding domains (TMDs) and nucleotide-binding domains (NBDs). The TMDs are specific to their substrates, whereas the NBDs are similar to engines that complete ATP hydrolysis to complete the substrate transport. They can be full transporters consisting of two TMDs and NBDs, half transporters with one TMD and NBD, while some encoded with a single TMD or NBD are...
5.7K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

14.4K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
14.4K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

64.7K
Overview
64.7K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

3.7K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination.

Proceedings of the National Academy of Sciences of the United States of America·2020
Same author

Cell Death Response to DNA Damage.

The Yale journal of biology and medicine·2019
Same author

DNA damage-induced cell death relies on SLFN11-dependent cleavage of distinct type II tRNAs.

Nature structural & molecular biology·2018
Same author

Nuclear respiratory factor 1 promotes spheroid survival and mesenchymal transition in mammary epithelial cells.

Oncogene·2018
Same author

Extracellular vesicles transfer nuclear Abl-dependent and radiation-induced miR-34c into unirradiated cells to cause bystander effects.

Molecular biology of the cell·2018
Same author

EnABLing microprocessor for apoptosis.

Molecular & cellular oncology·2016

Related Experiment Video

Updated: May 4, 2026

Functional Complementation Analysis FCA: A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways
09:27

Functional Complementation Analysis FCA: A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways

Published on: June 24, 2016

17.3K

The capable ABL: what is its biological function?

Jean Y J Wang1

  • 1Department of Medicine, Division of Hematology-Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.

Molecular and Cellular Biology
|January 15, 2014
PubMed
Summary
This summary is machine-generated.

The ABL1 gene

More Related Videos

Associated Chromosome Trap for Identifying Long-range DNA Interactions
14:49

Associated Chromosome Trap for Identifying Long-range DNA Interactions

Published on: April 23, 2011

14.9K
Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System
05:06

Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Published on: January 5, 2024

1.3K

Related Experiment Videos

Last Updated: May 4, 2026

Functional Complementation Analysis FCA: A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways
09:27

Functional Complementation Analysis FCA: A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways

Published on: June 24, 2016

17.3K
Associated Chromosome Trap for Identifying Long-range DNA Interactions
14:49

Associated Chromosome Trap for Identifying Long-range DNA Interactions

Published on: April 23, 2011

14.9K
Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System
05:06

Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Published on: January 5, 2024

1.3K

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • The ABL1 gene encodes the ABL nonreceptor tyrosine kinase, a key regulator of cellular processes.
  • ABL kinase activity is implicated in diverse functions, including cell growth, survival, migration, and specialized roles in neurons and immune cells.
  • Paradoxically, ABL kinase activation is also linked to neurodegenerative diseases, presenting a complex functional profile.

Purpose of the Study:

  • To elucidate the multifaceted roles of the ABL1 gene and its encoded ABL tyrosine kinase.
  • To reconcile the diverse functions of ABL, from proto-oncogene to its involvement in neuronal degeneration.
  • To understand how ABL's structure and subcellular localization dictate its context-dependent activities.

Main Methods:

  • Analysis of ABL1 gene sequence and protein structure-function relationships.
  • Investigation of ABL mutant mouse phenotypes.
  • Identification and characterization of ABL kinase substrates.

Main Results:

  • ABL kinase is activated by various signals, influencing proliferation, differentiation, survival, and migration.
  • ABL shuttles between the nucleus and cytoplasm, interacting with DNA and actin.
  • ABL's function is context-dependent, serving diverse tissue-specific roles.

Conclusions:

  • The ABL1 gene product, ABL tyrosine kinase, does not adhere to a single function.
  • ABL's diverse capabilities arise from its molecular blueprint, enabling regulation by location and interactions.
  • ABL has evolved to fulfill various tissue-specific and context-dependent biological functions.