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Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
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Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
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Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
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Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
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Simple Continuous Glucose Monitoring in Freely Moving Mice
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Canagliflozin.

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  • 1Founder and Contributing Editor, The Formulary ;

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This summary is machine-generated.

The Formulary Monograph Service provides monthly drug monographs and utilization evaluations for Pharmacy & Therapeutics Committees. This service aids in informed medication decisions for newly released and pipeline drugs.

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Area of Science:

  • Pharmaceutical Sciences
  • Clinical Pharmacy
  • Drug Information

Background:

  • The Formulary Monograph Service offers detailed drug information.
  • It targets Pharmacy & Therapeutics Committees and healthcare professionals.
  • The service includes monographs for new and late-stage trial drugs.

Purpose of the Study:

  • To provide timely and comprehensive drug information to healthcare professionals.
  • To support informed decision-making in formulary management.
  • To facilitate drug utilization reviews and medication use evaluations.

Main Methods:

  • Publication of 5-6 detailed monographs monthly.
  • Inclusion of 1-page summary monographs for pharmacy and nursing in-services.
  • Provision of a comprehensive drug utilization evaluation/medication use evaluation (DUE/MUE) monthly.

Main Results:

  • Subscribers receive print and online access to monographs.
  • Monographs can be customized to facility needs.
  • A monthly drug class review is now included.

Conclusions:

  • The Formulary Monograph Service is a valuable resource for drug information and formulary management.
  • The service supports evidence-based medication use.
  • Timely updates on new drugs like dolutegravir and ibrutinib are provided.