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Updated: May 4, 2026

A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust
Published on: January 6, 2023
Silica associated mixed connective tissue disorder in a stone crusher
Arjun Khanna1, Jagdish Chander Suri2, Animesh Ray2
1Department of Pulmonary, Critical Care and Sleep Medicine, Safdarjung Hospital and VMMC, New Delhi, India.
Abstract:
Silica exposure has been implicated with the development of various connective tissue diseases. We report a case of 32-year-old stone crusher who developed silicosis with mixed connective tissue disorder (MCTD) 6 years after exposure to silica. This association of silicosis with MCTD has never been reported from the Indian subcontinent, although the problem of this pneumoconiosis remains rampant. This rare association urges us to report this case.
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