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Plasma fibroblast growth factor 23, parathyroid hormone, 25-hydroxyvitamin D3, and risk of heart failure: a

Romina di Giuseppe1, Brian Buijsse, Frank Hirche

  • 1Department of Epidemiology (R.d.G., B.B., J.W., M.A., H.B., C.W.), German Institute of Human Nutrition Potsdam-Rehbrücke, D-14558 Nuthetal, Germany; Institute of Agricultural and Nutritional Sciences (F.H., G.I.S.), Human Nutrition Group, Martin-Luther-University Halle-Wittenberg, D-06108 Halle, Germany; Department for Clinical Chemistry and Pathobiochemistry (S.W., B.I.), Otto-von-Guericke-University Magdeburg, 39106 Magdeburg, Germany; Institute of Epidemiology and Social Medicine (H.W.H.), Clinical Epidemiology Unit, University of Münster, D-48129 Münster, Germany; Department of Clinical Medicine (J.D.), University of Bergen, N-5020 Bergen Norway; and Institute for Social Medicine, Epidemiology, and Health Economics (C.W.), Charité University Medical Center, 10117 Berlin, Germany.

The Journal of Clinical Endocrinology and Metabolism
|January 16, 2014
PubMed

Insights

Higher levels of fibroblast growth factor 23 (FGF23) are linked to an increased risk of heart failure (HF). The study found no clear association for parathyroid hormone (PTH) or 25-hydroxyvitamin D3 [25(OH)D3] with HF risk.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Research

Background:

  • Bone mineral metabolism is increasingly recognized for its potential role in the pathogenesis of heart failure (HF).
  • Specific biomarkers such as fibroblast growth factor 23 (FGF23), parathyroid hormone (PTH), and 25-hydroxyvitamin D3 [25(OH)D3] are implicated in mineral metabolism and may influence cardiovascular health.

Purpose of the Study:

  • To investigate the association between plasma levels of FGF23, PTH, and 25(OH)D3 and the incidence of congestive heart failure (HF).
  • To examine these relationships in a population-based cohort of middle-aged men and women.

Main Methods:

  • A prospective case-cohort study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort.
  • The study included 221 incident congestive HF cases and 1228 individuals without HF, with a mean follow-up of 8.2 years.

Main Results:

  • Each doubling of FGF23 was associated with a 29% increased risk of HF (HR, 1.29; 95% CI, 1.07-1.56) after multivariable adjustment.
  • PTH was not significantly related to HF risk (HR per doubling, 1.21; 95% CI, 0.99-1.48), although an interaction with obesity suggested a potential link.
  • No significant association was found between 25(OH)D3 and HF risk (HR per doubling, 1.02; 95% CI, 0.73-1.41).

Conclusions:

  • Epidemiological evidence supports a positive relationship between elevated FGF23 levels and an increased risk of developing heart failure.
  • The role of PTH in HF development requires further investigation, particularly in obese populations.
  • Plasma 25(OH)D3 levels do not appear to be associated with incident HF in this cohort.
Abstract

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