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Updated: May 4, 2026
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Growth patterns of pituitary adenomas and histopathological correlates
Eric Monsalves1, Soroush Larjani, Bruno Loyola Godoy
1Institute of Medical Science (E.M., S.E., G.Z.) and Department of Laboratory Medicine and Pathobiology (O.M.), University of Toronto, Toronto, Canada M5T 2S8; Divisions of Neurosurgery (E.M., S.L., B.L.G., K.J., F.C., F.G., G.Z.) and Division of Radiology (W.K.), and Departments of Medicine (S.E.) and Pathology (O.M.), University Health Network, Toronto, Canada M5G 2C4; and Division of Neurosurgery (A.K.), Hospital for Sick Children, Toronto, Canada M5G 1X8.
Context:
The factors associated with pituitary adenoma (PA) growth rate remain unclear.
Objective:
The objective of the study was to establish whether the preoperative growth and extension pattern of PA can predict postoperative growth rate and recurrence in addition to whether the PA growth rate correlates with proliferation and growth factor expression.
Patients:
One hundred fifty-three consecutive patients who underwent surgery for pituitary adenoma from 1999 to 2011 at Toronto Western Hospital were identified.
Main Outcome Measures:
The PA growth rate was measured both pre- and postoperatively, and its association with patient demographics, magnetic resonance imaging, and histolopathological parameters was determined.
Results:
The preoperative growth rate was associated with age (P = .0001), suprasellar growth (P = .003), the presence of a cyst/hemorrhage (P = .004), the mindbomb homolog-1 (P = .005), fibroblast growth factor receptor-4 positivity (P = .047), and p27 negativity (P = .007). After surgery, there were 34.6% residual volumes, which were associated with older age (P = .038) and also with growth patterns including anterior, posterior, suprasellar, and cavernous sinus extension (P = .001); 43.3% of these residuals grew and postoperative growth rate was calculated. Pre- and postoperative growth rates were correlated (r = 0.497, P = .026). Postoperative growth rate was associated with age (P = .015) and gender (P = .017).
Conclusions:
Our data suggest that the growth rate of PAs are influenced by various patient- and tumor-specific characteristics including the age and sex of the patient, the specific subtype of PA, its hormonal activity, its immunohistochemical profile including the mindbomb homolog 1 labeling index status, and its preponderance for different growth directions relative to the pituitary fossa. Furthermore, the pre- and postoperative PA growth rates were correlated, suggesting that postoperative PA growth rates can be predicted, in part, by preoperative growth rates, thus better informing postoperative outcome.
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