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Updated: May 4, 2026
Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots
Published on: August 16, 2020
Does systemic low-grade inflammation associate with fat accumulation and distribution? A 7-year follow-up study with
Xinfei Wen1, Satu Pekkala, Renwei Wang
1School of Kinesiology (X.W., R.W., Y.L., P.C., S.C.), Shanghai University of Sport, Shanghai 200438, China; Department of Health Sciences (X.W., S.P., P.W., S.M.C., X.T., Y.L., S.C.), University of Jyväskylä, FIN-40014 Jyväskylä, Finland; National Center for Public Health Surveillance and Information Services (G.F.), Chinese Center for Disease Control and Prevention, Beijing 102206, China; Department of General Practice and Primary Health Care (J.G.E.), Helsinki University, and Unit of General Practice (J.G.E.), Helsinki University Central Hospital, FIN-00290 Helsinki, Finland; Folkhälsan Research Centre (J.G.E.), FIN-00250 Helsinki, Finland; Department of Medical Rehabilitation (P.W., S.M.C., M.A.), Oulu University Hospital, FIN-90221, Oulu, Finland; and Institute of Health Sciences, University of Oulu, FIN-90220 Oulu, Finland.
Context:
Knowledge about the interrelationship between adiposity and systemic low-grade inflammation during pubertal growth is important in detecting early signs of obesity-related metabolic disorders.
Objective:
The objective of the study was to evaluate the developmental trajectories of fat mass (FM) and high sensitive C-reactive protein (hsCRP) levels and factors that could explain the relationship between FM and hsCRP in girls from prepuberty to early adulthood.
Design:
This was a 7.5-year longitudinal study.
Setting:
The study was conducted at the University of Jyväskylä Sports and Health Science laboratory.
Participants:
Three hundred ninety-six healthy Finnish girls aged 11.2 ± 0.8 years participated in the study.
Methods:
Body composition was assessed by a dual-energy X-ray absorptiometry and serum concentrations of hsCRP, adipokines, and sex hormones by ELISA.
Results:
Both FM and hsCRP increased with age and had similar trajectories but different inter- and intravariance patterns. A joint analysis of fat distribution and hsCRP indicated that the linkage probabilities across different trajectory subgroups between regional FM and the corresponding hsCRP levels varied from 16% to 53%. In a longitudinal regression model, the common predictor for both FM and hsCRP was T (β = .065, P < 0.01, and β = -.213, P < 0.05, respectively) before menarche. Other factors predicting FM before menarche were SHBG (β = -.196, P < 0.01) and leptin (β = .381, P < .01); and after menarche hsCRP (β = .048, P < 0.01), T (β = .089, P < .01), leptin (β = .340, P < .01), and adiponectin (β = -.086, P < .05). Of the factors assessed, only FM was associated with hsCRP both before and after menarche (β =1.058, P < .01 and β =1.121, P < .01, respectively).
Conclusions:
The differences in regional body fat depots and hsCRP levels in adulthood are largely established early in childhood. However, the intra- and interindividual variances differed between FM and hsCRP. FM explained the variance of hsCRP during pubertal growth, but the reverse was not true, which suggests that FM contributes to low-grade inflammation and not vice versa.
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