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Paper spray-MS for bioanalysis.

Cheng-Huang Lin1, Wei-Ching Liao, Hsin-Kai Chen

  • 1Department of Chemistry, National Taiwan Normal University, 88 Sec. 4, Tingchow Road, Taipei, Taiwan.

Bioanalysis
|January 16, 2014
PubMed
Summary
This summary is machine-generated.

Paper spray-mass spectrometry (MS) offers a simplified, rapid direct sampling and ionization technique for ambient analysis. This versatile method shows significant potential across diverse applications, from biological samples to foodstuffs and drugs.

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry

Background:

  • Paper spray-mass spectrometry (MS) is an emerging direct sampling/ionization technique.
  • It simplifies and accelerates mass spectrum analysis under ambient conditions.

Purpose of the Study:

  • To provide a comprehensive understanding of paper spray-MS.
  • To review its fundamental principles, modifications, and diverse applications.

Main Methods:

  • Discussion of the core methodology and theory of paper spray-MS.
  • Review of modifications such as nib-assisted, droplet monitoring, high-throughput, leaf, tissue, and wooden tip spray.
  • Examination of recent applications in analyzing dried blood spots (DBS), foodstuffs, drugs, and oil.

Main Results:

  • Paper spray-MS significantly simplifies and speeds up mass spectrometry analysis.
  • Various modifications enhance its versatility and applicability.
  • Demonstrated potential in direct analysis of biological and chemical samples.

Conclusions:

  • Paper spray-MS is a rapidly growing and important technique in mass spectrometry.
  • It offers a fast, direct sampling and ionization method for ambient analysis.
  • Shows great potential for analyzing diverse sample types including DBS, food, drugs, and oil.