Related Experiment Video
Updated: May 4, 2026

Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
Published on: October 13, 2023
[Clinical characteristics of primary biliary cirrhosis complicating Sjögren syndrome]
Li-xia Gao1, Li Wang1, Feng-chun Zhang1
1Department of Rheumatology, Peking Union Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing 100032, China.
Objective:
To explore the clinical characteristics of primary biliary cirrhosis (PBC) with Sjögren syndrome (SS) so as to seek diagnostic rationales.
Methods:
Sixty-four PBC patients, 57 SS patients and 93 PBC with SS patients were recruited from Peking Union College Hospital between 2006 and 2009. And their clinical, laboratory and pathological data were analyzed.
Results:
The patients of PBC with SS (53 ± 10) years were older than those of PBC (50 ± 11) years (P < 0.05) or SS (48 ± 14) years (P < 0.05) ; Comparing PBC with SS and SS, fever was more in SS (P < 0.05) ;compare with PBC, the positive rates of anti-centromere antibody (ACA) (P < 0.05) and anti-SSA antibody (P < 0.05) increased obviously in PBC with SS. Comparing with SS, the positive rate of anti-SSA antibody (P < 0.05) and anti-SSB antibody (P < 0.05) were apparently increased obviously in PBC with SS.
Conclusion:
PBC with SS is a special subgroup with the characteristic both PBC and SS. But it can not differentiate from PBC or SS, Anti-SSA antibody and ACA are helpful for diagnosis of PBC with SS.
More Related Videos
Related Concept Videos
Inflammatory Bowel Disease IV: Clinical Manifestations
Chronic Pancreatitis II: Pathophysiology
Cirrhosis I: Introduction
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Cirrhosis II: Pathophysiology
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...

