Related Experiment Video
Updated: May 4, 2026

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib
Published on: April 3, 2026
[A case of liver and bone metastasis from gastrointestinal stromal tumor treated using imatinib]
Masahiro Murakami1, Chikara Ebisui, Kazuyuki Okada
1Dept. of Surgery, Osaka Rosai Hospital.
Abstract:
A 71-year-old man with an unspecified gastric tumor had undergone gastrectomy 15 years previously, and in 2012, positron emission tomography-computed tomography(PET-CT)showed the presence of a bulky tumor located in the right hepatic liver and multiple bone metastases. Although it was unclear whether the tumor was primary or metastatic, liver biopsy was performed. Immunostaining revealed that the lesions were positive for c-kit, and therefore, these lesions were diagnosed as liver and bone metastases from gastric gastrointestinal stromal tumor(GIST). Chemotherapy with imatinib was initiated. PET-CT performed after 3 months revealed a marked decrease in fluorodeoxyglucose(FDG)accumulation. The patient is alive at present with no recurrence.

