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MMP-9: biomarker for abdominal aneurysm

C A Affirul1, I M Azim, H Hanafiah

  • 1Surgery Department, Medical Faculty and Allied Health, Islamic Science University of Malaysia, 13th Floor, MPAJ Building, Kuala Lumpur.

La Clinica Terapeutica
|January 16, 2014
PubMed
Abstract

Insights

Matrix Metalloproteinase 9 (MMP-9) levels correlate with Abdominal Aortic Aneurysm (AAA). However, MMP-9 has limited diagnostic utility for AAA due to low sensitivity and specificity.

Area of Science:

  • Vascular Biology
  • Biomarker Discovery
  • Cardiovascular Research

Background:

  • Matrix Metalloproteinase 9 (MMP-9) is significantly expressed in Abdominal Aortic Aneurysm (AAA) tissue.
  • Previous studies suggest MMP-9 as a potential biomarker for AAA, but findings have been conflicting.
  • This study investigates the correlation between MMP-9 levels and AAA to clarify its utility as a biomarker.

Purpose of the Study:

  • To determine the correlation between Matrix Metalloproteinase 9 (MMP-9) concentration levels and Abdominal Aortic Aneurysm (AAA).
  • To evaluate the utility of MMP-9 as a diagnostic biomarker for AAA in the studied population.

Main Methods:

  • Prospective controlled trial involving 20 AAA patients and 36 healthy controls.
  • MMP-9 concentrations measured using enzyme-linked immunosorbent assay (ELISA).
  • Comparison of MMP-9 levels with abdominal imaging (ultrasonography or CT).

Main Results:

  • MMP-9 levels were significantly correlated with AAA (p=0.004).
  • Mean MMP-9 was 21.39 ± 1.03 ng/mL in AAA patients versus 23.94 ± 0.60 ng/mL in controls (p < 0.05).
  • Sensitivity and specificity for MMP-9 as an AAA biomarker were 60% and 64%, respectively, with a cutoff of 12.54.

Conclusions:

  • MMP-9 levels show a significant correlation with Abdominal Aortic Aneurysm (AAA).
  • The diagnostic utility of MMP-9 for AAA is limited by its low sensitivity and specificity.
  • MMP-9 has restricted value in predicting AAA presence or absence.

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