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Angiotensin II promotes the progression of human gastric cancer

Ming-Min Huang1, Ai-Bin Guo1, Jun-Feng Sun2

  • 1Department of Gerontics, Drum Tower Hospital, College of Medicine, Nanjing University, Nanjing, Jiangsu 210008, P.R. China.

Molecular Medicine Reports
|January 16, 2014
PubMed

Insights

The renin-angiotensin system (RAS) is activated in gastric cancer, with angiotensin II (Ang II) promoting tumor growth and cell migration. Blocking the Ang II type 1 receptor (AT1R) with losartan inhibited these effects, suggesting a therapeutic target.

Area of Science:

  • Oncology
  • Cardiovascular Research
  • Molecular Biology

Background:

  • The renin-angiotensin system (RAS) is crucial for cardiovascular homeostasis, angiogenesis, and cell proliferation.
  • Dysregulation of RAS components is implicated in various cancers.

Purpose of the Study:

  • To investigate the expression of key RAS components in gastric cancer tissue.
  • To determine the role of angiotensin II (Ang II) in gastric cancer progression, including cell growth, migration, and proliferation.

Main Methods:

  • Quantification of Ang II, Ang II type 1 receptor (AT1R), Ang II type 2 receptor (AT2R), and angiotensin-converting enzyme (ACE) activity in gastric cancer tissues versus healthy controls.
  • In vivo studies using a nude mouse model with MKN45 human gastric cancer cells, treated with Ang II and losartan (an AT1R antagonist).
  • In vitro studies assessing the effects of Ang II and losartan on MKN45 cell migration and proliferation.

Main Results:

  • Elevated levels of Ang II, AT1R, AT2R, and ACE activity were observed in gastric cancer tissues compared to healthy tissues.
  • Ang II administration significantly increased tumor size and weight in nude mice, an effect reversed by losartan treatment.
  • Ang II enhanced the migration and proliferation of MKN45 cells, while losartan significantly inhibited these processes.

Conclusions:

  • The renin-angiotensin system is activated in gastric cancer.
  • Angiotensin II promotes gastric cancer progression by enhancing tumor growth, migration, and proliferation.
  • Targeting the AT1R with antagonists like losartan may represent a potential therapeutic strategy for gastric cancer.

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