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Published on: October 1, 2016
An effective automated glucose sensor for fermentation monitoring and control
I Queinnec1, C Destruhaut, J B Pourciel
1INSA, UA CNRS 544, Centre de Transfert en Biotechnologie et Microbiologie, DGBA, 54 Avenue de Rangueil, F-31077, Toulouse cédex, France.
Abstract:
An industrial glucose analyser was partnered to an automated injection system to evaluate glucose in the culture medium of a bioreactor. This sensor has been validated on continuous cultures ofSchizosaccharomyces pombe and continuous and fed-batch cultures ofSaccharomyces cerevisiae. In addition to the advantage of a more accurate process monitoring, the main interest of this sensor deals with the control of the substrate concentration to a prespecified reference signal. Several experiments have been carried out first to validate the sensor, then to control the process evolution.
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