Related Experiment Video

Updated: May 4, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

22.3K

[A psychocardiology update on depression and coronary heart disease]

Roland von Känel1

  • 1Kompetenzbereich für Psychosomatische Medizin, Klinik für Allgemeine Innere Medizin, Universitätsspital, Inselspital, Bern und Departement für Klinische Forschung, Universität Bern.

Praxis
|January 16, 2014
PubMed

Insights

Major depressive disorder affects 20% of patients post-myocardial infarction. Depression is a significant risk factor for coronary heart disease and impacts recovery, necessitating integrated treatment approaches.

Area of Science:

  • Cardiology
  • Psychiatry
  • Immunology

Context:

  • Major depressive disorder (MDD) prevalence is 20% in post-myocardial infarction (MI) patients.
  • Depression is a known risk factor for developing coronary heart disease (CHD) and predicts poorer outcomes after MI.

Purpose:

  • To explore the link between depression and cardiovascular disease post-MI.
  • To identify factors contributing to depression after acute coronary events.
  • To highlight therapeutic strategies and future research directions.

Summary:

  • Post-MI depression is linked to lifestyle, adherence, metabolic, and pathophysiologic factors.
  • Acute coronary events, immune, and inflammatory changes may uniquely contribute to incident depression.
  • Treatments include psychotherapy, antidepressants, and exercise, with cardiac rehabilitation reducing mortality risk.

Impact:

  • Understanding the depression-MI link can improve patient prognosis.
  • Identifying cardiotoxic aspects of depression may lead to novel therapeutic targets.
  • Integrated care for cardiovascular and mental health is crucial for better patient outcomes.

Keywords:
DepressionEntzündungMyokardinfarktTherapiedepressioninfarctus du myocardeinflammationmyocardial infarctionpsychological stresspsychologischer Stressstress psychologiquetherapythérapie

More Related Videos

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

31.9K
Caspase-3 Activity in the Rat Amygdala Measured by Spectrofluorometry After Myocardial Infarction08:41

Caspase-3 Activity in the Rat Amygdala Measured by Spectrofluorometry After Myocardial Infarction

Published on: January 12, 2016

15.4K

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
757
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
943
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.2K
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
522
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
884
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
1.3K