Lisinopril in elderly patients with hypertension

Area of Science:

• Geriatrics
• Cardiology
• Pharmacology

Background:

• Hypertension is a prevalent condition in elderly individuals.
• Effective and safe antihypertensive treatments are crucial for this demographic.
• Angiotensin-converting enzyme (ACE) inhibitors are a common class of antihypertensive drugs.

Purpose of the Study:

• To evaluate the antihypertensive efficacy and safety of lisinopril in elderly patients.
• To assess the tolerability and optimal dosing of lisinopril in this population.
• To determine the impact of lisinopril on blood pressure and potential adverse effects.

Main Methods:

• An open-label study of 12 weeks' duration was conducted.
• 40 elderly patients (≥65 years) with mild to moderate hypertension were enrolled.
• Lisinopril was administered orally in single daily doses, with dose titration and optional addition of a thiazide diuretic.

Main Results:

• Mean sitting blood pressure was significantly reduced following lisinopril treatment.
• No significant changes in heart rate or incidence of postural hypotension were observed.
• Lisinopril was well-tolerated, with minimal adverse events and no significant haematological or biochemical changes.

Conclusions:

• Lisinopril is a well-tolerated and effective antihypertensive therapy for elderly patients.
• The drug demonstrated significant blood pressure reduction without compromising safety parameters.
• Further research may explore long-term outcomes and comparative effectiveness in this population.