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Related Experiment Videos

Histamine release in anesthesia and surgery.

J Moss

    New England and Regional Allergy Proceedings
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    General anesthesia can trigger histamine release, causing cardiovascular changes. Combined H1 and H2 antagonists may prevent these anaphylactoid reactions and their effects.

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    Area of Science:

    • Anesthesiology and Pharmacology

    Background:

    • General anesthesia can induce histamine release, leading to anaphylactic and anaphylactoid reactions.
    • Narcotics and muscle relaxants are known in vitro and in vivo triggers of significant histamine release.
    • Histamine release during anesthesia correlates with cardiovascular system changes.

    Purpose of the Study:

    • To evaluate the efficacy of combined H1 and H2 antagonists in attenuating anaphylactoid reactions during general anesthesia.
    • To explore the prophylactic potential of H1 and H2 antagonists against immunologically mediated reactions.

    Main Methods:

    • Review of controlled trials investigating the use of combined H1 and H2 antagonists in humans.
    • Analysis of recent clinical experience with chymopapain administration.

    Main Results:

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    • Controlled trials demonstrate the effectiveness of combined H1 and H2 antagonists in mitigating the effects of anaphylactoid reactions.
    • Clinical data suggest a potential role for H1 and H2 antagonists in preventing immunologically mediated reactions.

    Conclusions:

    • Combined H1 and H2 antagonists are effective in managing anaphylactoid reactions during general anesthesia.
    • Prophylactic use of H1 and H2 antagonists may be beneficial for preventing immunologically mediated reactions in surgical settings.