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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Tissue Transplantation01:24

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Related Experiment Video

Updated: May 4, 2026

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
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Liver transplantatation- an overview.

Rakesh Rai1

  • 1Senior Consultant Surgeon HPB & Transplant Surgery, Fortis Hospital, Mulund (W), Mumbai, India.

The Indian Journal of Surgery
|January 16, 2014
PubMed
Summary
This summary is machine-generated.

Liver transplantation significantly improves survival for end-stage liver disease patients. Advances in organ donation, including living donor liver transplantation (LDLT) and donation after cardiac death (DCD), address organ shortages and enhance patient outcomes.

Keywords:
End-stage liver diseaseLiver transplantationLiving donor

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Area of Science:

  • Hepatology
  • Transplant Surgery
  • Organ Donation

Background:

  • End-stage liver disease (ESLD) historically had high mortality rates.
  • Liver transplantation is a life-saving intervention for acute and chronic liver failure.
  • Shortage of organs from donation after brain death (DBD) necessitates alternative strategies.

Purpose of the Study:

  • To review established indications, contraindications, and procedures for liver transplantation.
  • To discuss alternative organ sources like split liver, living donor liver transplantation (LDLT), and donation after cardiac death (DCD).
  • To highlight the improved survival rates achieved with modern liver transplantation.

Main Methods:

  • Review of established liver transplantation protocols.
  • Analysis of organ procurement strategies, including DBD, LDLT, and DCD.
  • Evaluation of patient survival data pre- and post-transplantation.

Main Results:

  • Liver transplantation survival rates exceed 85% at 1 year and 70% at 5 years.
  • Alternative organ sources (split liver, LDLT, DCD) are increasingly utilized.
  • Significant reduction in mortality compared to the pre-transplantation era.

Conclusions:

  • Liver transplantation offers a definitive treatment for end-stage liver disease.
  • Diversification of organ sources is crucial to manage waiting list mortality.
  • Modern liver transplantation provides substantial long-term survival benefits.